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Schaemic heart disease 5. The following patient groups were represented: elderly. hyperlipidaemia. iabetes mellitus. atients with hypertension.

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tadalafil, vardenafil data from controlled clinical trials indicate that ocular effects do occur with other PDE type 5 inhibitors. Such visual abnormalities probably result from sildenafil's pharmacologic activity at retinal photoreceptors secondary to inhibition of PDE type 6.

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Single doses of antacid magnesium hydroxide/aluminium hydroxide did not affect the bioavailability of sildenafil. Stronger CYP3A4 inhibitors such as ketoconazole and itraconazole would be expected to have greater effects. Co-administration of the HIV protease inhibitor saquinavir, a CYP3A4 inhibitor, at steady state 1200mg three times a day with sildenafil 100mg single dose resulted in a 140% increase in sildenafil Cmax and a 210% sildenafil 50mg tablets uk in sildenafil AUC.

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